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This approach aims to minimize potential risks while still reaping benefits 8

In contrast, persistently stabilized NRF2 in response to KEAP1 or NRF2 mutations causes sustained activation of these genes, leading to the accumulation of xCT/SLC7A11, GCLC, and GCLM that cause a depletion of intracellular glutamate (Sayin et al

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Despite methodological differences across studies, including inclusion criterion, sample collection, disease status, or additional confounders, contributing to divergent microbial profiles, the evidence of microbial dysbiosis in PD is consistent (Romano et al., 2021